Convergent MurJ flippase inhibition by phage lysis proteins

· · 来源:pro资讯

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The woman who ultimately discovered the superior features of agar as a growth medium and brought it to Koch’s attention was Fanny Angelina Hesse. Her foundational contribution to the nascent field of microbiology is often omitted from textbooks. In other cases, she is unflatteringly referred to as a “German housewife” or as “Frau Hesse,” or dismissed as an unnamed technician.

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但这种垄断格局,即将被打破,多款在研新药正从作用机制到给药方式,向Vosoritide发起挑战。Ascendis的TransCon-CNP通过包裹技术延长了药物作用时间,实现了周剂给药,目前正处于FDA审批阶段;而BridgeBio的口服药Infigratinib,则从作用机制到用药体验实现全面突破。

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